Table 2.

Detailed antiviral activity of compounds 3 and 4 against SARS-CoV-2

Compound	EC50	EC75	EC99	CC50
	(μM)	(μM)	(μM)	(μM)
5h (2)	1.9 ± 0.50	4.3 ± 0.58	8.4 ± 0.23	>100
3	0.23 ± 0.030	0.46 ± 0.020	0.97 ± 0.0020	>100
4	0.28 ± 0.045	0.59 ± 0.030	4.1 ± 3.1	>100
PF-07321332 (1)	1.9 ± 0.18	4.4 ± 0.21	9.7 ± 0.015	>100

EC₅₀, EC₇₅, and EC₉₉ values were determined with RNA-qPCR and CC₅₀ values were determined with WST-8 assays, using VeroE6 cells.

Numbers represent the average EC₅₀ value ± SD (μM) and CC₅₀ value ± SD (μM) from two independent experiments.