Table 4.
Association between cg12869254 with OCT/A measurements in univariable and multivariable linear regression models
| OCT/A measurements* | Univariable model 1 | Multivariable model 2§ | ||||
|---|---|---|---|---|---|---|
| β | 95% CI | P value† | β | 95% CI | P value† | |
| SCP VD, % | ||||||
| Superior | 0.4 | (− 1.6, 2.2) | 0.695 | − 0.2 | (− 2.5, 2.0) | 0.828 |
| Inferior | − 0.6 | (− 3.0, 1.7) | 0.582 | − 0.3 | (− 3.5, 2.9) | 0.839 |
| Nasal | 1.4 | (− 0.6, 3.3) | 0.164 | 1.3 | (1.0, 3.6) | 0.241 |
| Temporal | 0.01 | (− 2.7, 2.7) | 0.990 | − 1.7 | (− 5.3, 1.9) | 0.321 |
| DCP VD, % | ||||||
| Superior | 0.1 | (− 1.0, 1.1) | 0.895 | 0.2 | (− 1.1, 1.5) | 0.728 |
| Inferior | − 0.7 | (− 2.1, 0.7) | 0.322 | 0.1 | (− 2.0, 2.2) | 0.917 |
| Nasal | − 0.2 | (− 1.3, 0.9) | 0.702 | 0.2 | (− 1.1, 1.5) | 0.806 |
| Temporal | − 0.8 | (− 2.5, 0.9) | 0.334 | − 0.7 | (− 2.7, 1.3) | 0.444 |
| RNFL thickness, µm | ||||||
| Superior | − 2.6 | (− 5.1, − 0.2) | 0.039 | − 3.0 | (− 5.8, − 0.2) | 0.035 |
| Inferior | − 0.4 | (− 2.4, 1.6) | 0.666 | 0.3 | (− 2.4, 3.0) | 0.790 |
| Nasal | − 2.6 | (− 4.4, − 0.7) | 0.009 | − 2.2 | (− 4.4, − 0.1) | 0.049 |
| Temporal | 0.2 | (− 2.0, 2.4) | 0.843 | 0.4 | (− 2.1, 2.8) | 0.749 |
OCT/A = optical coherence tomography/angiography; SCP = superficial capillary plexus; VD = vessel density; DCP = deep capillary plexus; RNFL = retinal nerve fiber layer; CI = confidential interval; T2DM = type 2 diabetes mellitus; HbA1c = glycated hemoglobin
§Adjusted for age, sex, T2DM duration and HbA1c. *Per percent of methylation change. †Bold indicates statistically significant