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Schematic diagram and potential roles of de novo mutations in NOTCH1 genes in neurodevelopmental diseases. A. Schematic diagram of NOTCH1 gene, and de novo mutations (p.V999M and p.S1027L) found in this study. B. The potential roles of NOTCH1 signaling in neurodevelopmental diseases. This figure was adapted from Sanchez-Martin and Ferrando [24] and Arumugam et al. [25]
