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. 2022 Nov 1;241:109678. doi: 10.1016/j.drugalcdep.2022.109678

Table 4.

Fixed and random parameter estimates for linear mixed models predicting the total number of months of MOUD utilization among those who utilized care, between cohorts and over time.


Buprenorphine Number of Months (n = 23,915)
Methadone Number of Months (n = 6394)
Naltrexone Number of Months (n = 9126)
Fixed Effects Est. (SE) Est. (SE) Est. (SE)
Intercept 8.76(0.06)* ** 8.86(0.10)* ** 4.19(0.07)* **
Agea .12(0.03)* ** 1.00(0.07)* ** 0.19(0.04)* **
Gender
(male ref.)
-0.04(0.11) -0.22(0.29) 0.18(0.12)
Race/Ethnicity
(White ref.)
-1.08(0.07)* ** -0.80(0.13)* ** -0.03(0.07)
Rural vs. Urban
(urban ref.)
0.23(0.07)* ** 0.03(0.15) -0.33(0.08)* **
CCIa -.66(0.04)* ** -0.26(0.06)* ** -0.20(0.04)* **
PDGa -.01(0.03) -0.23(0.07)* ** 0.24(0.03)* **
Year 1 vs. 2
(year 1 ref.)
0.15(0.05)* * -1.49(0.09)* ** -0.01(0.08)
Cohort
(comparison cohort ref.)
0.03(0.07) -0.77(0.13)* ** 0.08(0.08)
Cohort X Year 0.27(0.07)* ** 1.18(0.14)* ** -0.10(0.11)
Random effects SD SD SD
Level 2
Interceptb 3.70 3.95 1.99
Level 1
Residual 3.11 2.92 2.64

Note: CCI = Charlson Comorbidity Index; PDG = Psychiatric Diagnosis Groups; Est. = Estimate; SE = Standard Error; SD = Standard Deviation

a Centered and standardized to overcome scale differences and facilitate model convergence

b Parameter estimate of between person variance around fixed intercept.

p < .10, *p < .05, * *p < .01, * **p < .001