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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Bone. 2022 Jul 21;163:116502. doi: 10.1016/j.bone.2022.116502

Figure 1.

Figure 1.

Overview of study design. Three separate tamoxifen inducible Cre-ERT2 mouse lines (UBC, Osx, or Dmp1) were crossed to mice carrying floxed VEGFA (Vegfafl/fl) alleles. At 20 weeks of age (5 mo) mice received 5 daily doses of tamoxifen followed by a 3-week clearance. An initial group was euthanized at 24 weeks of age (day 0) and tibia were used for strain calibration. Separate cohorts of mice were loaded daily for 5 days and euthanized 12 days after the start of loading for dynamic histomorphometry outcomes. (Created with BioRender.com)