FIGURE 2.
Hras G12V mutation trigger a femoral bone loss in CS mice at defined ages and CS mice that survive beyond median lifespan are not affected by a bone loss. (A) µCT measurements of cortical bone in CS females and males. (B) 3D reconstructed cortical bone images from 15- and 12-month-old females and males, respectively. µCT measurements of trabecular bone in CS females (C) and males (D). 3D reconstructed cortical bone images of 15-month-old females (E) and 12-month-old-males (F). 5 months females (n = 3–4), 15 months females (n = 4), 5 months males (n = 3–4), 12 months males (n = 34–5). Data are shown as mean ± SEM. Statistical differences were analysed by unpaired 2-tailed student’s t-test where *p < 0.05, **p < 0.01.