Table 1.
Studies included in the analysis.
| Reference, first author | Year | Study design | N a | UC | CD | US elastography technique | US device | Results on accuracy of USE |
|---|---|---|---|---|---|---|---|---|
| Stidham RW17 | 2011 | Case series | 7 | 7 | SE | Zonare Medical Systems [Z-1], Mountain View, CA | Fibrostenotic bowel was stiffer than the normal tissue resection margins in all subjects [p = .0009] | |
| Havre RF18 | 2014 | Prospective | 9 | 9 | SE | HV900 [Hitachi Medical Corporation, Tokyo, Japan] | Mean SR of 3.33 [SD, 5.21] in CD patients with increased tissue fibrosis [score ≥1] | |
| Dillman JR19 | 2014 | Prospective | 11 | 3 | 8 | pSWE/2D-SWE | Acuson S3000 [Siemens Medical Solutions USA, Inc., Mountain View, CA] | High fibrosis vs low fibrosis score segments showed significantly greater mean shear wave speed [p = 0.049] |
| Baumgart DC20 | 2015 | Prospective | 10 | 10 | SE | Hitachi [Lübbecke, Germany] | A higher collagen content was associated with RTE-assessed strain [p <0.001] and tensiometry-assessed strain [p <0.001] | |
| Fraquelli M21 | 2015 | Prospective | 23 | 23 | SE | Philips iU22 [Philips Healthcare, Bothell, WA] | Area under the receiver operating characteristic curve: 0.917 [95% CI, 0.788 to 1.000] | |
| Giannetti A27 | 2016 | Case report | 1 | 1 | SE | Mylab Twice, Esaote, Italy | The SE pattern of reduced elasticity corresponded to histological fibrosis | |
| Lu C22 | 2017 | Prospective | 105 | 105 | pSWE | Philips Epiq 5,Philips IU-22 [Philips Healthcare,Bothell, WA] or Acuson S3000, [Siemens Medical Solutions, Malvern, PA] | Moderate correlation between SWE and muscular hypertrophy [r = 0.59, p = 0.02] | |
| Serra C23 | 2017 | Prospective | 26 | 26 | SE | iU22 Philips [Philips, Bothell, WA, USA] | No significant correlation was found between mean SR and fibrosis score [ p= 0.877]. | |
| Chen YJ24 | 2018 | Prospective,cross-sectional | 35 | 35 | pSWE/2D-SWE | SuperSonic Imagine S.A., Aix-en-Provence, France | Sensitivity of 69.6% and specificity of 91.7% with AUC of 0.822 [95% CI, 0.685 to 0.960] [p = 0.002] | |
| Quaia E25 | 2018 | Prospective | 20 | 20 | SE | iU22 Philips[Philips, Bothell, WA, USA] | Overall accuracy of SE alone of 30% to 35% in distinguishing fibrotic bowel; increased accuracy when combined with CEUS, US | |
| Ding SS26 | 2019 | Retrospective | 25 | 25 | SE, pSWE/2D-SWE | S2000 [Siemens Medical Solutions, Mountain View, CA] | Sensitivity of 75% and specificity of100%, accuracy of 96% [p <.05] for p-SWE [cutoff value >2.73 m/s] | |
| Thimm MA28 | 2019 | Case report | 3 | 3 | pSWE | EPIC scanner [Philips Healthcare] | Increased level of stiffness [1.58 m/s] consistent with histological fibrosis |
IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn’s disease; US, ultrasound; USE, ultrasound elatography; SE, strain elastography; pSWE, point shear wave elastography; 2D-SWE, two-dimensional shear wave elastography; NS, not specified; SR, strain ratio; SD, standard deviation; AUC, area under the curve; SD, standard deviation; CI, confidence interval; CEUS, contrast enhanced US; RTE, real-time elastography.
Exclusively IBD patients.