FIG. 2.

Intracellular bacterial survival and replication of S. aureus, P. aeruginosa, and Acinetobacter in U937 cells primed with 10 μg of LPS per ml and then exposed to graded concentrations of methylprednisolone. (These experiments were done in duplicate.) Gray bars, U937 monocytic cells primed with LPS alone; hatched bars, U937 cells primed with LPS and then exposed to methylprednisolone (0, 25, 50, 75, 100, 150, and 250 μg per ml). Standard errors for each bacterial species were estimated from the square root of the mean square error from ANOVA divided by the square root of 2, and the P values reflect the probability that the the mean intracellular bacterial survival and replication of primed U937 cells with exposure to methylprednisolone is equal to the mean of primed U937 cells without exposure ∗, P = 0.0001.