Skip to main content
. 2022 Oct 4;7(4):151. doi: 10.3390/biomimetics7040151

Table 2.

Growth factors commonly incorporated in tissue-engineered scaffolds (Adapted from Whitaker, M. et al. [299]).

Growth Factor Target & Application in Tissue Engineering Fabrication Methods References
Bone morphogenetic protein-2 (BMP-2) Bone regeneration; Cell proliferation 3D-printing; Bioprinting; Electrospinning;
Gas foaming; Hydrogel; Cryogel; Solvent Casting/Particulate Leaching
[300,301,302,303,304,305,306,307,308]
Epidermal growth factor (EGF) Cell proliferation; Neural Stem Cell Differentiation; Wound healing Bioprinting; Electrospinning; Gas foaming; Hydrogel; Cryogel; Solvent Casting/Particulate Leaching [309,310,311,312,313,314,315,316,317,318]
Fibroblast growth factor (FGF) Angiogenesis; Bone/Cartilage Regeneration; Cell Proliferation; Nerve Growth 3D-printing;
Electrospinning; Gas Foaming; Solvent Casting/Particulate Leaching
[262,263,314,319,320,321,322,323,324,325,326,327]
Nerve growth factor (NGF) Axonal Growth; Neurite Extension in Central and Peripheral Nervous Systems 3D-printing; Bioprinting; Electrospinning;
Hydrogel; Cryogel
[260,328,329,330,331,332,333,334,335,336]
Platelet-derived growth factor (PDGF) Angiogenesis; Endothelial Cell Proliferation; Wound Healing 3D-printing; Electrospinning; Gas foaming; Hydrogel [326,337,338,339,340,341,342,343]
Transforming growth factor-β (TGF-β) Bone/Cartilage
Regeneration; ECM Production
3D-printing; Bioprinting; Electrospinning; Hydrogel; Cryogel; Solvent Casting/Particulate Leaching [325,326,341,344,345,346,347,348,349,350]
Vascular endothelial growth factor (VEGF) Angiogenesis; Endothelial Cell Proliferation
3D-printing; Bioprinting;
Electrospinning; Gas foaming; Hydrogel;
Cryogel; Solvent Casting/Particulate Leaching
[264,303,304,318,351,352,353,354,355,356,357]