Table 3.
The immunoglobulin IgG1 receptor, chain and domain structure labels and correspondence with sequence labels. IMGT standardized labels are in capital letters. They are shown with the example Homo sapiens IgG1-kappa.
| IG Structure Labels (IMGT/3Dstructure-DB [27,28,29]) |
Sequence Labels (IMGT/LIGM-DB [24,25]) | |||
|---|---|---|---|---|
| Receptor | Chain | Domain Type | Domain | Region 1 |
| IG-GAMMA-1_KAPPA | H-GAMMA-1 | V | VH | V-D-J-REGION |
| C | CH1 | C-REGION 2 | ||
| C | CH2 | |||
| C | CH3 | |||
| L-KAPPA | V | V-KAPPA | V-J-REGION | |
| C | C-KAPPA | C-REGION | ||
1. The VH-domain (or V-D-J-REGION) and the VL-domain (V-KAPPA or V-LAMBDA) (or V-J-REGION) are encoded by rearranged V-(D)-J genes, whereas the remainder of the chain is the C-REGION (encoded by a C gene). The C-REGION comprises one C-domain (C-KAPPA or C-LAMBDA) for the L chain, or several C-domains (CH) for the H chain. 2 The heavy chain C-REGION also includes the HINGE-REGION, and for membrane IG (mIG), the CONNECTING-REGION (CO), TRANSMEMBRANE-REGION (TM) and CYTOPLASMIC-REGION (CY); for secreted IG (sIG), the C-REGION includes CHS instead of CO, TM and CY.