Table 16.
IMGT Engineered Variant Name | IMGT Engineered Variant Definition | IMGT Amino Acid Changes on IGHG CH Domain (Eu Numbering between Parentheses) | Amino Acid Changes with the Eu Positions | Motif Identifiable in Gene and Domain with Positions According to the IMGT Unique Numbering and with Eu Positions between Parentheses | Property and Function |
---|---|---|---|---|---|
G4v5
|
h
P10 |
h S10 > P(228) |
S228P |
IGHG4 h 1–12 (216–230) ESKYGPPCPSCP > ESKYGPPCPPCP (G1-like) |
Prevents in vivo and in vitro IgG4 half-IG exchange [129] |
G4v6 |
CH3
K88 |
CH3 R88 > K |
R409K |
IGHG1 CH3 85.4–89 (404–410) GSFFLYSRL > GSFFLYSKL |
Reduces IgG4 half-IG exchange [141] |