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. 2022 Oct 18;11(4):65. doi: 10.3390/antib11040065

Table 16.

IMGT nomenclature, Eu positions and IMGT motif of engineered Fc variants involved in the prevention of IgG4 half-IG exchange (Structure #12).

IMGT Engineered Variant Name IMGT Engineered Variant Definition IMGT Amino Acid Changes on IGHG CH Domain (Eu Numbering between Parentheses) Amino Acid Changes with the Eu Positions Motif Identifiable in Gene and Domain with Positions According to the IMGT Unique Numbering and with Eu Positions between Parentheses Property and Function
G4v5
h
P10
h
S10 > P(228)

S228P
IGHG4 h
1–12 (216–230)
ESKYGPPCPSCP >
ESKYGPPCPPCP
(G1-like)
Prevents in vivo and in vitro IgG4 half-IG exchange
[129]
G4v6 CH3
K88
CH3
R88 > K

R409K
IGHG1 CH3
85.4–89 (404–410)
GSFFLYSRL >
GSFFLYSKL
Reduces IgG4 half-IG exchange [141]