Table 17.

IMGT nomenclature, Eu positions and IMGT motif of engineered Fc variants involved in hexamerisation (Structure #13).

IMGT Engineered Variant Name	IMGT Engineered Variant Definition	IMGT Amino Acid Changes on IGHG CH Domain (Eu Numbering between Parentheses)	Amino Acid Changes with the Eu Positions	Motif Identifiable in Gene and Domain with Positions According to the IMGT Unique Numbering and with Eu Positions between Parentheses	Property and Function
G1v34	CH3 G109	CH3 E109 > G (430)	E430G	IGHG1 CH3- FG 105–117 (426–437) SVMHEA.LHNHYT > SVMHGA.LHNHYT	Favors IgG1 hexamerisation by increased intermolecular Fc-Fc interactions after antigen binding on the cell surface