Table 19.
IMGT nomenclature, Eu positions and IMGT motif of engineered Fc variants involved in the suppression of inter H-L and/or inter H-H disulfide bridges (Structure #15).
| IMGT Variant Name | IMGT Variant Description | IMGT Amino Acid Changes on IGHG CH Domain with Eu Numbering between Parentheses | Eu Numbering Variant | Motif Identifiable in Gene and Domain with Positions According to the IMGT Unique Numbering | Property and Function |
|---|---|---|---|---|---|
| G1v37 |
h
S5 |
h C5 > S (220) |
C220S |
IGHG1 h 1–15 (216–230) EPKSCDKTHTCPPCP > EPKSSDKTHTCPPCP |
No disulfide bridge inter H-L |
| G1v61 |
h
S11 |
h C11 > S (226) |
C226S |
IGHG1 h 1–15 (216–230) EPKSCDKTHTCPPCP > EPKSCDKTHTSPPCP |
No disulfide bridge inter H-H h 11 |
| G1v62 |
h
S14 |
h C14 > S (229) |
C229S |
IGHG1 h 1–15 (216–230) EPKSCDKTHTCPPCP > EPKSCDKTHTCPPSP |
No disulfide bridge inter H-H h 14 |