Table 2.

The P values of linear regression models analyzing the associations between individual taxa and case/control adjusted for covariates (see Methods) in the ASC and DES colon microbiome

	ASC colon								DES colon
	Model 1		Model 2		Model 3		Model 4		Model 1		Model 2		Model 3		Model 4
	t value	FDR	t value	FDR	t value	FDR	t value	FDR	t value	FDR	t value	FDR	t value	FDR	t value	FDR
p__Proteobacteria—c__Gammaproteobacteria—o__Betaproteobacteriales	−3.22	0.26	−3.11	0.18	−3.64	0.12	−3.64	0.12	−4.31	0.009	−4.14	0.017	−3.80	0.07	−3.77	0.08
p__Proteobacteria—c__Gammaproteobacteria—o__Betaproteobacteriales—f__Burkholderiaceae	−2.96	0.26	−2.89	0.2	−3.36	0.16	−3.40	0.14	−3.87	0.024	−3.76	0.037	−3.33	0.09	−3.30	0.16
p__Proteobacteria—c__Gammaproteobacteria—o__Betaproteobacteriales—f__Burkholderiaceae—g__Sutterella—s__unclassified	−2.55	0.28	−2.53	0.24	−2.95	0.24	−2.73	0.26	−3.42	0.058	−3.33	0.045	−2.69	0.16	−2.28	0.25
p__Proteobacteria—c__Gammaproteobacteria—o__Pasteurellales—f__Pasteurellaceae—g__Haemophilus—s__unclassified	−1.04	0.79	−1.08	0.69	−1.49	0.65	−1.07	0.87	−3.38	0.058	−3.18	0.045	−3.24	0.09	−2.59	0.16
p__Proteobacteria—c__Gammaproteobacteria—o__Pasteurellales—f__Pasteurellaceae—g__Haemophilus	−1.04	0.79	−1.08	0.69	−1.49	0.65	−1.07	0.87	−3.38	0.058	−3.18	0.045	−3.23	0.09	−2.59	0.16
p__Proteobacteria—c__Gammaproteobacteria—o__Betaproteobacteriales—f__Burkholderiaceae—g__Sutterella	−2.31	0.35	−2.32	0.31	−2.70	0.24	−2.50	0.29	−3.2	0.063	−3.16	0.045	−2.51	0.18	−2.10	0.31
p__Proteobacteria—c__Gammaproteobacteria—o__Pasteurellales	−1.14	0.71	−1.17	0.64	−1.55	0.65	−1.16	0.87	−3.04	0.063	−2.83	0.081	−2.57	0.18	−2.11	0.31
p__Proteobacteria—c__Gammaproteobacteria—o__Pasteurellales—f__Pasteurellaceae	−1.14	0.71	−1.17	0.64	−1.55	0.65	−1.16	0.87	−3.04	0.063	−2.83	0.081	−2.57	0.18	−2.11	0.31
p__Proteobacteria—c__Gammaproteobacteria	−2.95	0.26	−3.31	0.18	−2.99	0.24	−3.10	0.14	−3.03	0.063	−3.25	0.045	−2.36	0.21	−2.38	0.22
p__Proteobacteria	−2.91	0.26	−3.28	0.18	−2.99	0.24	−3.08	0.14	−2.96	0.063	−3.17	0.045	−2.29	0.23	−2.33	0.23
p__Firmicutes—c__Bacilli—o__Lactobacillales—f__Streptococcaceae—g__Streptococcus—s__unclassified	−1.47	0.54	−1.22	0.62	−1.74	0.52	−1.73	0.57	−2.95	0.063	−2.83	0.081	−3.08	0.09	−2.71	0.16
p__Firmicutes—c__Bacilli—o__Lactobacillales	−1.62	0.52	−1.39	0.56	−1.82	0.51	−1.85	0.57	−2.94	0.063	−2.83	0.081	−3.06	0.09	−2.76	0.16
p__Firmicutes—c__Bacilli—o__Lactobacillales—f__Streptococcaceae	−1.46	0.54	−1.22	0.62	−1.74	0.52	−1.73	0.57	−2.93	0.063	−2.82	0.081	−3.07	0.09	−2.68	0.16
p__Firmicutes—c__Bacilli—o__Lactobacillales—f__Streptococcaceae—g__Streptococcus	−1.47	0.54	−1.22	0.62	−1.74	0.52	−1.74	0.57	−2.93	0.063	−2.82	0.081	−3.07	0.09	−2.69	0.16
p__Bacteroidetes—c__Bacteroidia—o__Bacteroidales—f__Marinifilaceae	−2.82	0.26	−2.79	0.21	−2.16	0.40	−1.92	0.55	−2.88	0.068	−2.77	0.083	−2.09	0.31	−1.95	0.35
p__Proteobacteria—c__Gammaproteobacteria—o__Betaproteobacteriales—f__Neisseriaceae—g__Neisseria	−1.96	0.4	−1.68	0.51	−2.55	0.25	−2.24	0.35	−2.74	0.094	−2.42	0.16	−2.56	0.18	−2.58	0.16
p__Proteobacteria—c__Gammaproteobacteria—o__Betaproteobacteriales—f__Neisseriaceae—g__Neisseria—s__unclassified	−1.96	0.4	−1.68	0.51	−2.55	0.25	−2.24	0.35	−2.74	0.094	−2.42	0.16	−2.56	0.18	−2.58	0.16
p__Proteobacteria—c__Gammaproteobacteria—o__Betaproteobacteriales—f__Neisseriaceae	−2.05	0.37	−1.78	0.51	−2.65	0.24	−2.41	0.29	−2.73	0.094	−2.41	0.16	−2.56	0.18	−2.57	0.16
p__Bacteroidetes—c__Bacteroidia—o__Bacteroidales—f__Marinifilaceae—g__Odoribacter—s__unclassified	−2.08	0.37	−2.34	0.31	−2.09	0.40	−2.21	0.36	−2.52	0.15	−2.71	0.09	−2.37	0.21	−2.62	0.16
p__Proteobacteria—c__Gammaproteobacteria—o__Enterobacteriales	−2.64	0.28	−3.03	0.18	−2.70	0.24	−2.85	0.21	−2.47	0.16	−2.79	0.08	−2.03	0.33	−2.05	0.31
p__Proteobacteria—c__Gammaproteobacteria—o__Enterobacteriales—f__Enterobacteriaceae	−2.64	0.28	−3.03	0.18	−2.70	0.24	−2.85	0.21	−2.47	0.16	−2.79	0.08	−2.03	0.33	−2.05	0.31
p__Firmicutes—c__Clostridia—o__Clostridiales—f__Lachnospiraceae—g__Blautia	1.92	0.4	2.14	0.34	1.32	0.75	1.15	0.87	2.36	0.19	2.67	0.1	1.40	0.57	1.16	0.63
p__Firmicutes—c__Clostridia—o__Clostridiales—f__Lachnospiraceae—g__Blautia—s__unclassified	1.92	0.4	2.14	0.34	1.32	0.75	1.15	0.87	2.36	0.19	2.67	0.1	1.40	0.57	1.16	0.63
p__Firmicutes—c__Negativicutes—o__Selenomonadales—f__Acidaminococcaceae—g__Phascolarctobacterium—s__unclassified	2.09	0.37	2.47	0.26	2.66	0.24	2.43	0.29	2.62	0.12	2.86	0.08	2.70	0.16	2.46	0.19
p__Actinobacteria	2.19	0.36	2.32	0.31	1.99	0.42	1.73	0.57	2.88	0.07	3.05	0.06	2.45	0.20	2.26	0.26
p__Actinobacteria—c__Coriobacteriia—o__Coriobacteriales—f__Coriobacteriaceae—g__Collinsella	2.5	0.28	2.56	0.24	2.38	0.29	2.18	0.36	3.09	0.06	3.28	0.05	2.84	0.12	2.60	0.16
p__Actinobacteria—c__Coriobacteriia—o__Coriobacteriales—f__Coriobacteriaceae—g__Collinsella—s__unclassified	2.5	0.28	2.56	0.24	2.38	0.29	2.18	0.36	3.09	0.06	3.28	0.05	2.84	0.12	2.60	0.16
p__Actinobacteria—c__Coriobacteriia—o__Coriobacteriales—f__Coriobacteriaceae	2.53	0.28	2.58	0.24	2.40	0.29	2.20	0.36	3.1	0.06	3.3	0.05	2.86	0.12	2.62	0.16
p__Actinobacteria—c__Coriobacteriia	2.8	0.26	2.85	0.2	2.68	0.24	2.45	0.29	3.27	0.06	3.45	0.05	3.06	0.09	2.83	0.16
p__Actinobacteria—c__Coriobacteriia—o__Coriobacteriales	2.8	0.26	2.85	0.2	2.68	0.24	2.45	0.29	3.27	0.06	3.45	0.05	3.06	0.09	2.83	0.16

Bold numbers indicate significant differences (FDR <0.1).

ASC, ascending; DES, descending; FDR, false discovery rate.