Table 5.

Spearman correlations^a for baseline associations of dietary intervention components with circulating BAs in the Polyp Prevention Trial, 1991–1998 (N = 170 super compliers and N = 198 goal-achieving controls)

BA concentration, ng/mL	Fiber		Fat		Fruits and vegetables
	Rs	P FDR b	Rs	P FDR b	Rs	P FDR b
Chenodeoxycholic acid	−0.09	0.21	0.00	0.99	0.00	0.99
Cholic acid	−0.04	0.63	−0.02	0.81	0.04	0.65
Deoxycholic acid	−0.10	0.14	−0.04	0.66	0.01	0.90
Glycochenodeoxycholic acid	−0.17	0.07	−0.05	0.60	0.12	0.12
Glycocholic acid	−0.12	0.12	−0.03	0.66	0.12	0.12
Glycodeoxycholic acid	−0.14	0.12	−0.06	0.41	0.10	0.16
Glycolithocholic acid	−0.09	0.18	−0.13	0.12	0.03	0.75
Glycoursodeoxycholic acid	−0.12	0.12	−0.06	0.42	0.11	0.13
Lithocholic acid	−0.09	0.20	−0.11	0.13	0.00	0.99
Taurochenodeoxycholic acid	−0.14	0.12	−0.03	0.66	0.08	0.29
Taurocholic acid	−0.11	0.13	−0.02	0.81	0.09	0.19
Taurodeoxycholic acid	−0.12	0.12	−0.04	0.65	0.10	0.14
Ursodeoxycholic acid	−0.11	0.14	−0.04	0.66	0.06	0.41
Summary scores
Total bile acids	−0.15	0.02	−0.06	0.38	0.09	0.19
Primary bile acidsc	−0.15	0.02	−0.03	0.56	0.10	0.12
Secondary bile acidsd	−0.14	0.03	−0.07	0.25	0.05	0.42

BA, bile acid; FDR, false discovery rate.

^aSpearman correlations were adjusted for age at randomization; sex (female/male); intervention arm (control/intervention); body mass index at baseline; baseline adenoma characteristics (advanced/multiple or early adenoma); education (college graduate vs postgraduate college); recruitment center (California, New York/Pennsylvania/Illinois/North Carolina/Virginia, Utah); baseline smoking status (current smoker, former smoker, never regular smoker); family history (yes, no, or missing); regular nonsteroidal anti-inflammatory drug/aspirin use (yes or no); total energy; and nutrient density-adjusted fiber, fat, and fruit and vegetable intakes.

^bP values adjusted for multiple testing using FDR correction using the Benjamin-Hochberg method.

^cPrimary BAs = log₂ of the sum of chenodeoxycholic acid, cholic acid, glycocholic acid, glycochenodeoxycholic acid, taurocholic acid, and taurochenodeoxycholic acid.

^dSecondary BAs = log₂ of the sum of deoxycholic acid, lithocholic acid, glycodeoxycholic acid, glycolithocholic acid, and taurodeoxycholic acid.