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. 2022 Aug 31;13(10):e00524. doi: 10.14309/ctg.0000000000000524

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© 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Cohort 1: Gut microbiome tryptophan metabolism during acute COVID-19, stratified based on GI and depression/anxiety symptoms at 6 months of follow-up. GI and depression/anxiety symptoms were classified in 13 patients at 6 months of follow-up after COVID-19. Tryptophan metabolism was imputed from 16S sequencing results from longitudinal samples gathered for up to 30 days after the diagnosis of COVID-19. GI symptoms were classified based on IBS-SSS points and depression/anxiety symptoms based on responses to EQ-5D-5L, which characterizes depression/anxiety on a 4-point Likert scale (none, mild, moderate, and severe). P values are for a repeated-measures mixed model incorporating between-patients and within-patients effects. COVID-19, coronavirus-19 disease; GI, gastrointestinal; IBS-SSS, Irritable Bowel Syndrome Severity Scoring System.