TABLE 4.
Initial and peak inflammatory mediator levels in plasma
| Mediator | No clinical focus of infection
|
KW Pa | Clinical focus of infection
|
KW P | ||||
|---|---|---|---|---|---|---|---|---|
| Negative culture (n = 61) | Positive local culture (n = 20) | Positive blood culture (n = 7) | Negative culture (n = 106) | Positive local culture (n = 60) | Positive blood culture (n = 46) | |||
| Complement 3a (nmol/liter) | ||||||||
| Initial | 7.5 (2.4–23) | 7.1 (3.2–52) | 15.0 (8.6–21) | <0.05 | 8.2 (2.3–68) | 8.9 (2.2–21) | 10.0 (3.5–52) | <0.05 |
| Peak | 8.8 (3.0–45) | 8.9 (4.8–52) | 18.0 (11.0–54) | <0.005 | 9.5 (3.6–101) | 11.0 (4.1–36) | 15.0 (4.8–59) | <0.01 |
| IL-6 (pg/ml) | ||||||||
| Initial | 18 (2.4–906) | 23 (4–775) | 130 (21–825) | <0.005 | 26 (1.4–418) | 30 (2–3,502) | 56 (4–8,952) | <0.01 |
| Peak | 26 (3.1–1,168) | 26 (6.9–775) | 130 (27–825) | <0.01 | 29 (1.9–630) | 33 (4–3,205) | 72 (4–8,952) | <0.001 |
| Secretory phospholipase A (ng/ml) | ||||||||
| Initial | 99 (1–1,500) | 171 (2–1,500) | 252 (12–1,500) | <0.05 | ||||
| Peak | 178 (2–1,760) | 262 (5–1,250) | 413 (18–1,250) | <0.01 | ||||
a
KW, Kruskal-Wallis test.