Table 1.
Baseline characteristics by uromodulin tertile
| Characteristic | Tertile 1, n=122 | Tertile 2, n=121 | Tertile 3, n=121 |
|---|---|---|---|
| Demographics | |||
| Age, yr | 58 (49–66) | 59 (46–67) | 57 (43–68) |
| Women, n (%) | 52 (43) | 51 (42) | 59 (49) |
| Black race, n (%) | 42 (35) | 23 (19) | 26 (22) |
| Diabetes, n (%) | 51 (43) | 46 (38) | 31 (26) |
| Hypertension, n (%) | 93 (76) | 91 (75) | 82 (68) |
| Cirrhosis, n (%) | 8 (7) | 9 (8) | 10 (8) |
| CKD, n (%) | 87 (80) | 84 (72) | 56 (50) |
| Body mass index, kg/m2 | 30 (25–33) | 29 (25–35) | 28 (24–33) |
| Medication use, n (%) | |||
| PPI use | 44 (36) | 44 (37) | 46 (38) |
| NSAID use | 20 (17) | 17 (14) | 29 (24) |
| Antibiotic use | 42 (35) | 53 (45) | 67 (56) |
| Prebiopsy laboratory features | |||
| Creatinine, mg/dla | 1.8 (1.3–2.6) | 1.4 (1.1–2.0) | 1.2 (0.8–1.6) |
| eGFR, ml/mina | 35 (24–58) | 50 (30–68) | 63 (42–99) |
| Protein-creatinine ratio, mg/mg | 2.1 (0.7–4.4) | 1.7 (0.7–4.6) | 1.5 (0.5–4.6) |
| Albumin-creatinine ratio, mg/mg | 1.0 (0.1–2.2) | 0.7 (0.1–2.7) | 0.7 (0.1–1.9) |
| Features at biopsy | |||
| AKI or AKD, n (%) | 100 (82) | 95 (79) | 78 (64) |
| Dialysis, n (%) | 6 (5) | 4 (3) | 7 (6) |
| Creatinine, mg/dl | 4.0 (2.3–6.3) | 2.5 (1.7–3.6) | 1.9 (1.2–3.0) |
| BUN, mg/dl | 49 (32–72) | 36 (27–52) | 32 (21–57) |
| Bicarbonate, serum, mEq/L | 20 (17–23) | 22 (19–25) | 23 (20–25) |
| Hemoglobin, g/dl | 10.4 (8.7–11.9) | 10.5 (8.9–11.9) | 10.8 (9.2–12.9) |
| Kidney size, cm | 11.2 (10.2–12.3) | 11.4 (10.8–12.2) | 11.6 (10.7–12.7) |
Data are interquartile ranges or proportion. Tertile 1, 0.14–0.81 μg/g; tertile 2, 0.82–1.65 μg/g; tertile 3, 1.67–12.24 μg/g. Chi-squared and nonparametric trend tests. PPI, proton pump inhibitor; NSAID, nonsteroidal anti-inflammatory drug; AKD, acute kidney disease.
a
Prebiospy creatinine and eGFR values were obtained 1–6 months prior to kidney biopsy.