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Characterization of multiple classes of anti-HCV present in serum and oral fluid. Paired serum-oral fluid samples were screened by HCV 3.0 ELISA using enzyme-conjugated antibodies specific for human IgG, IgM, or IgA, respectively. (A) In serum, high levels of anti-HCV IgG- and IgM-class antibodies are detectable, while relatively little anti-HCV IgA is present. (B) In oral fluid, the majority of antibodies detectable are of the IgG or IgA class, with little or no anti-HCV IgM present.
