Table 3.
Comparison of clinical parameters and radiographic assessment before and after statin treatment in 40 PAP patients.
| Parameter | At baseline | 12-month follow-up | p value |
|---|---|---|---|
| TC (mmol/L) | 4.20 ± 0.86 | 3.35 ± 0.75 | <0.001 |
| TG (mmol/L) | 1.75 ± 1.19 | 1.33 ± 0.80 | 0.066 |
| HDL (mmol/L) | 1.15 ± 0.43 | 1.29 ± 0.35 | 0.092 |
| LDL (mmol/L) | 2.50 ± 0.75 | 1.60 ± 0.64 | <0.001 |
| TC/HDL | 4.07 ± 1.34 | 2.68 ± 0.59 | <0.001 |
| LDH (U/L) | 268.23 ± 90.51 | 230.28 ± 60.02 | 0.030 |
| CEA (ng/mL) | 3.90 ± 4.33 | 3.31 ± 2.49 | 0.459 |
| CYF21-1 (ng/mL) | 9.31 ± 8.08 | 5.87 ± 4.31 | 0.021 |
| PaO2 (mmHg) | 69.31 ± 11.49 | 74.78 ± 9.64 | 0.024 |
| Alveolar arterial oxygen gradient (A-aDO2) (mmHg) | 34.29 ± 13.48 | 29.08 ± 12.19 | 0.074 |
| Disease severity score | 2.63 ± 1.01 | 2.13 ± 0.79 | 0.016 |
| FVC%pred | 79.01 ± 17.78 | 83.65 ± 17.55 | 0.244 |
| FEV1%pred | 80.19 ± 18.39 | 83.28 ± 18.02 | 0.450 |
| DLCO%pred | 60.26 ± 20.90 | 70.15 ± 21.04 | 0.038 |
| Total opacification percentage of whole lung (%) | 32.49 ± 24.15 | 20.96 ± 21.34 | 0.026 |
| Opacification percentage of right upper lobe (%) | 35.69 ± 27.76 | 26.51 ± 25.17 | 0.125 |
| Opacification percentage of right middle lobe (%) | 31.26 ± 24.55 | 19.20 ± 20.78 | 0.020 |
| Opacification percentage of right lower lobe (%) | 34.29 ± 28.71 | 23.56 ± 27.01 | 0.089 |
| Opacification percentage of left upper lobe (%) | 31.50 ± 23.51 | 22.11 ± 20.96 | 0.063 |
| Opacification percentage of left lower lobe (%) | 29.58 ± 26.78 | 20.39 ± 23.76 | 0.109 |
| Percentage of HU value of (-∞,-750)H (%) | 5.54 ± 5.34 | 5.14 ± 5.26 | 0.741 |
| Percentage of HU value of [-750,-300)H (%) | 17.83 ± 14.28 | 13.04 ± 13.99 | 0.133 |
| Percentage of HU value of [-300, 49)H (%) | 7.19 ± 7.20 | 3.47 ± 4.94 | 0.009 |
| Percentage of HU value of [50+)H (%) | 1.85 ± 2.48 | 0.79 ± 1.34 | 0.021 |
TC: total cholesterol; TG: triglyceride; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol; LDH: lactate dehydrogenase; CEA: carcinoembryonic antigen; CYFRA21-1: cytokeratin 21-1; PaO2: partial pressure of arterial oxygen; FVC: forced vital capacity; FEV1: forced expiratory volume in one second; DLCO: carbon monoxide diffusion capacity; HU: Hounsfield unit.