FIGURE 7.

PTPL1 inhibits growth of xenograft lung cancer in vivo through downregulation of YAP1. (a) Mice were subcutaneously challenged by parental A549 cells, those subjected to PTPL1 or concurrent YAP1 knockdown (n = 5), and the bodyweights of mice were monitored. (a–c) A549 cells treated with sh‐mock lentivirus were subcutaneously inoculated to the flanks, sh‐PTPL1 and shPTPL1 + shYAP1 lentivirus were treated to the flanks of nude mice. The tumor growth curves showed that compared with the sh‐mock group, the sh‐PTPL1 group inhibited tumor growth. (b) The tumor volumes of nude mice described in (a) measured and plotted. (c) Mice in (a) were sacrificed 28 days after inoculation, and tumors were isolated and weighed. The displayed data is the average ± SD (n = 5). (*p < 0.05, **p < 0.01, ***p < 0.001). PTPL1, protein‐tyrosine phosphatase‐L1; shmock, negative control; shPTPL1, short hairpin RNA against PTPL1; shYAP1, short hairpin RNA against YAP1; YAP1, yes‐associated protein