Skip to main content
. 2022 Jun 21;45(11):1634–1645. doi: 10.1007/s00270-022-03187-y

Table 4.

Summary of the published clinical findings deriving from the prospective studies completed so far

References Study Na Lesion type Main finding
Reinders-Hut et al. [28] HEPAR primary 31 HCC (87% multifocal disease) 166Ho-radioembolization is a safe treatment option for HCC patients with
 Unacceptable toxicity related to study treatment occurred in 10% of patients
 Complete or partial response for:
  54% of the target liver lesions at 3-month follow-up
  84% of the target liver lesions at 6-month follow-up
 Median overall survival was 14.9 months
Van Roekel et al. [27] SIM 21 Liver metastases (mCRC) Between anti-reflux and standard microcatheter
 No difference in tumor targeting
 No difference in infusion efficiency
 No influence on the dose–response rate
 Confirmed safety and efficacy in mCRC
Braat et al. [25] HEPAR PLuS 30 Liver metastases (NET) 166Ho radioembolization, as an adjunct to peptide receptor radionuclide therapy is safe and efficacious, with
 Response (complete or partial) in the liver, according to RECIST 1.1
  43% at 3 months
  47% at 6 months
 Acceptable toxicity
 No loss in quality of life
Prince et al. [24] HEPAR II 37 Liver metastases (different origins) 166Ho radioembolization-induced a tumor response and acceptable toxicity profile in salvage patients with
 Complete response, partial response or stable disease of the target lesion obtained in 73% of population at 3-month follow-up
 Median overall survival of 14.5 months
Smits et al. [23] HEPAR I 15 Liver metastases (different origins) The maximum tolerated radiation dose was identified as 60 Gy (averaged over the perfused volume)
Stable disease or partial response regarding target lesions achieved:
 In 93% population at 6-week follow-up
 In 64% population at 12-week follow-up

T/N tumor to non-tumor ratio, RECIST response evaluation criteria in solid tumors, HCC hepatocellular carcinoma, MCRC metastatic colorectal cancer, NET neuroendocrine tumor

aNumber of subjects included in the referred article analyzing the mentioned study