This systematic review included 13 heterogeneous studies evaluating the impact of medication optimisation or pharmacological interventions (excluding single-drug trials) on cognitive function.

Most of the studies did not include medication optimisation (e.g., listing approaches) as an intervention, but used pharmacological interventions instead.

Five of the trials showed a positive impact on aspects of cognitive function.

Overall, there are few high-quality studies evaluating the impact of medication optimisation or drug interventions on cognitive functioning.

The improvement of cognitive function by these interventions should be addressed in future pharmacological studies.