Table 1.
ICU baseline characteristics during ICU stay.
| All patients | Range | |
|---|---|---|
| n | 184 | |
| Intubated at ICU admission | 133 (72.3%) | |
| ARDS mild at ICU admission | 14 (7.6%) | |
| ARDS moderate at ICU admission | 85 (46.2%) | |
| ARDS severe at ICU admission | 82 (44.6%) | |
| Septic shock at ICU admission | 24 (13.1%) | |
| First Horovitz-index at ICU | 108.8 (82.5; 150) | 45.0–450.0 |
| Lowest Horovitz-index at ICU | 60.0 (52.5; 75.0) | 22.5–225.0 |
| Pmean at admission [mbar] | 20 (17; 22) | 7–30 |
| PEEP at admission [mbar] | 14 (12; 15) | 6–20 |
| pH at admission | 7.38 (7.33; 7.44) | 6.81–7.62 |
| PaCO2 at admission [kPa] | 6.42 (5.64; 7.17) | 3.23–15.90 |
| SpO2 at admission [%] | 93 (90; 96) | 56–100 |
| SOFA score at ICU admission | 12 (10; 13) | 4–19 |
| D-dimers at ICU admission [ng/ml] | 5178 (2326; 8936) | 484–20,000 |
| Lactate at ICU admission [mmol/l] | 1.20 (0.90; 1.70) | 0.40–9.90 |
| Duration mechanical ventilation ICU [days] | 12 (7; 17) | 1–61 |
| Reintubation | 4 (2.2%) | |
| Prone position | 113 (61.4%) | |
| Cycles of prone position | 4 (2; 6) | 1–14 |
| Tracheostomy | 82 (44.6%) | |
| Days from intubation to tracheostomy | 12 (9; 15) | 3–26 |
| CRRT | 67 (36.4%) | |
| Duration CRRT [h] | 154.66 (31.51; 310.66) | 1.44–906.53 |
| ECMO | 49 (26.6%) | |
| Duration ECMO [h] | 274.66 (178.78; 353.04) | 16.78–1068.31 |
| Cytosorb | 8 (4.3%) | |
| Duration cytosorb [h] | 20.00 (17.17; 21.15) | 8.67–51.00 |
| Red cell transfusion | 6 (2; 12) | 1–40 |
| NO inhalation | 62 (33.7%) | |
| Corticosteroid | 165 (89.7%) | |
| Immunoglobulin | 4 (2.2%) | |
| Convalescent plasma | 34 (18.5%) | |
| Remdesivir | 20 (10.9%) | |
| Anticoagulation | 184 (100%) | |
| Argatroban at any time on ICU | 15 (8.2%) | |
| UFH at any time on ICU | 140 (76.1%) | |
| LMWH at any time on ICU | 115 (62.5%) | |
| Bacteremia | 92 (50%) | |
| Staph. aureus bacteremia | 12 (6.5%) | |
| Catheter associated bacteremia | 24 (13%) | |
| Antibiotics | 176 (95.7%) | |
| Antimycotics | 28 (15.2%) | |
| CRP maximum value [mg/l] | 261.2 (189.9; 342.1) | 31.4–618.0 |
| Interleukin 6 maximum value [pg/mL] | 359.5 (123.0; 755.5) | 8.6–792,732.0 |
| Leucocytes maximum value [GPt/L] | 19.06 (13.96; 25.91) | 3.14–63.87 |
| Leucocytes minimum value [GPt/L] | 7.22 (4.89; 9.46) | 0.20–22.47 |
| Procalcitonin [ng/ml] | 2.95 (0.91; 10.80) | 0.09–373.20 |
| Prothrombin fragment F1 + 2 [pmol/l] | 468 (272; 930) | 73–4948 |
| Platelets maximum value [GPt/L] | 315 (251; 418) | 48–989 |
| Platelets minimum value [GPt/L] | 124 (73; 198) | 1–469 |
Data are median (Interquartile range) or n (%).
ICU Intensive care unit, ARDS Acute respiratory distress syndrome, Pmean Mean pressure, PEEP Positive end-expiratory pressure, PaCO2 partial pressure of carbon dioxide, SpO2 Oxygen saturation, SOFA Sequential organ failure assessment, CRRT Continuous renal replacement therapy, NO Nitric oxide, UFH Unfractionated heparin, LMWH Low-molecular-weight heparin, Staph. Staphylococcus, CRP C-reactive protein, ECMO extracorporeal membrane oxygenation.