Table 7.
Cox regressions for hospital mortality.
| Variable | Bivariate regressions | Known at admission | Full model | |||
|---|---|---|---|---|---|---|
| HR | CI | HR | CI | HR | CI | |
| n | 184 | 184 | 184 | |||
| Age | 1.042** | 1.020–1.064 | 1.051 | 1.023–1.080 | 1.092 | 1.053–1.132 |
| Male | 1.454 | 0.916–2.306 | 1.490 | 0.917–2.422 | 1.411 | 0.795–2.501 |
| BMI: 35–40 kg/m2 | 0.884 | 0.492–1.586 | 1.178 | 0.630–2.206 | 1.922 | 0.961–3.843 |
| BMI: > 40 kg/m2 | 1.084 | 0.499–2.353 | 1.718 | 0.715–4.128 | 3.380* | 1.085–10.533 |
| CCI | 1.035 | 0.958–1.118 | 0.949 | 0.852–1.058 | 0.915 | 0.809–1.034 |
| Septic shock at ICU admission | 1.891* | 1.145–3.121 | 1.258 | 0.728–2.174 | 1.692 | 0.906–3.161 |
| SOFA score at ICU admission | 1.125** | 1.055–1.201 | 1.129** | 1.037–1.230 | 1.084 | 0.957–1.227 |
| D-Dimers at ICU admission: > 4000 ng/ml | 1.524 | 0.997–2.331 | 1.621* | 1.011–2.599 | 0.919 | 0.515–1.639 |
| Logarithm of first Horovitz-index at ICU | 0.901 | 0.580–1.399 | 0.949 | 0.573–1.571 | 1.369 | 0.741–2.530 |
| Direct transfer to our ICU from other hospital | 1.393 | 0.931–2.084 | 1.166 | 0.708–1.920 | 1.248 | 0.732–2.130 |
| Intubated at ICU admission | 1.652* | 1.054–2.589 | 0.836 | 0.445–1.570 | 0.879 | 0.403–1.917 |
| Time from first symptom to admission to our ICU | 1.015 | 0.996–1.036 | 1.009 | 0.985–1.034 | 1.008 | 0.983–1.034 |
| ECMO | 1.542* | 1.032–2.303 | 2.268* | 1.193–4.311 | ||
| CRRT | 1.864** | 1.274–2.726 | 1.216 | 0.684–2.162 | ||
| NO inhalation | 2.086** | 1.425–3.055 | 2.434** | 1.422–4.165 | ||
| Prone position | 1.071 | 0.714–1.605 | 1.108 | 0.641–1.917 | ||
| PE | 1.212 | 0.813–1.806 | 0.832 | 0.477–1.449 | ||
| Pneumothorax | 0.837 | 0.481–1.457 | 0.465 | 0.187–1.161 | ||
| Lung emphysema | 1.042 | 0.630–1.725 | 2.411 | 0.881–6.600 | ||
| Mediastinal emphysema | 1.009 | 0.534–1.904 | 0.896 | 0.247–3.247 | ||
| Pleural effusion | 1.215 | 0.830–1.776 | 0.915 | 0.561–1.492 | ||
| Bacteremia | 1.141 | 0.776–1.677 | 0.645 | 0.375–1.109 | ||
| Logarithm of lowest Horovitz-index at ICU | 0.357** | 0.199–0.640 | 0.414* | 0.189–0.907 | ||
| Leucocytes maximum value: > 20 GPt/l | 1.393 | 0.952–2.036 | 0.805 | 0.485–1.337 | ||
| Interleukin 6 maximum value: > 150 pg/ml | 2.272** | 1.335–3.869 | 2.115 | 0.914–4.893 | ||
| PCT maximum value: > 2 ng/ml | 2.290** | 1.462–3.588 | 1.832 | 0.938–3.577 | ||
| CRP maximum value: > 400 mg/l | 1.435 | 0.746–2.760 | 0.394 | 0.138–1.123 | ||
| CRP maximum value: 200–400 mg/l | 1.685 | 0.978–2.902 | 0.508 | 0.220–1.178 | ||
| Platelets maximum value: > 350 GPt/l | 0.488** | 0.320–0.746 | 0.541* | 0.302–0.969 | ||
| Platelets minimum value: < 100 GPt/l | 1.661** | 1.135–2.430 | 0.921 | 0.512–1.657 | ||
| Fusion in lung | 1.383 | 0.767–2.494 | 0.871 | 0.430–1.766 | ||
| Mycosis | 1.079 | 0.714–1.631 | 1.071 | 0.626–1.832 | ||
| Catheter associated bacteremia | 0.753 | 0.439–1.291 | 0.703 | 0.354–1.397 | ||
| Tracheostomy | 0.660* | 0.449–0.970 | 0.402** | 0.243–0.664 | ||
| DVT | 1.184 | 0.796–1.760 | 1.253 | 0.730–2.152 | ||
Hazard ratios with 95%-confidence intervals for hospital mortality from bivariate Cox regression, Cox regression including covariates known at admission and Cox regression including all covariates (full model) (significance levels: * = 5%, ** = 1%).
BMI Body-Mass-Index, CCI Charlson ComorbidityIndex, CI Confidence interval, CRP C-reactive protein, CRRT Continuous renal replacement therapy, DVT Deep vein thrombosis, ECMO extracorporeal membrane oxygenation, HR Hazard ration, ICU Intensive care unit, NO Nitric oxide, PCT Procalcitonin, PE Pulmonary embolism.