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. 2022 Oct 19;13:1027627. doi: 10.3389/fphar.2022.1027627

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Copyright © 2022 Ma, Dong, Huang, Yang, Geng, Fei, Xie, Zhao, Lin, Yang, Jin, Ju, Sun and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Subject disposition of participants in group A of the study (B) Subject disposition of participants in group B of the study. (C) Subject disposition of participants in group C of the study. PD, pharmacodynamics; PK, pharmacokinetics; qd, once daily; bid, twice a day, once in the morning and once in the evening. There was unwilling to see an error in the randomization system, resulting in three placebos and 13 trial drugs in group (B) (One subject withdrew due to an adverse event, and the substitute subject accepted the drug randomization).