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. 2022 Oct 19;13:1027627. doi: 10.3389/fphar.2022.1027627

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Copyright © 2022 Ma, Dong, Huang, Yang, Geng, Fei, Xie, Zhao, Lin, Yang, Jin, Ju, Sun and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean PK and PD data following administration of multiple doses of SHR2285 for 6 days (A) Time course of mean SHR2285 concentrations; (B) Time course of mean SHR164471 (metabolite of SHR2285) concentrations (C) Time course of mean ratio-to-baseline values for FXIa:C; (D) Time course of mean ratio-to-baseline values for APTT. APTT, activated partial thromboplastin time; FXIa:C, factor XIa coagulation activity; PD, pharmacodynamics; PK, pharmacokinetics.