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. 2022 Oct 19;13:1027627. doi: 10.3389/fphar.2022.1027627

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Copyright © 2022 Ma, Dong, Huang, Yang, Geng, Fei, Xie, Zhao, Lin, Yang, Jin, Ju, Sun and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation of SHR2285/SHR164471 unbound plasma concentrations with inhibition of FXI activity and APTT prolongation. In panel (A), the x-axis indicates sum of unbounded plasma concentration of SHR2285 and SHR164471*IC50 of SHR2285 on FXI activity/IC50 of SHR164471 on FXI activity. In panel (B), the x-axis represents the sum of unbounded plasma concentration of SHR2285 and SHR164471*CT2.0 of SHR2285 on APTT/CT2.0 of SHR164471 on APTT. The plasma-protein binding rate was measured using rapid equilibrium dialysis. Unbound plasma concentration = total plasma concentration*(1–protein binding%).