TABLE 5.
Pharmacodynamics indexes.
| Treatment (placebo or SHR2285) | |||||
|---|---|---|---|---|---|
| Placebo (A + B) n = 7 | Placebo(C) n = 8 | SHR2285 (A) n = 12 | SHR2285 (B) n = 13 | SHR2285 (C) n = 12 | |
| FXIa:C | |||||
| Inhibition maximum | 8.07 (3.37) | 14.6 (6.88) | 84.8 (4.66) | 89.3 (3.85) | 92.2 (1.66) |
| Inhibition average | -0.33 (4.88) | 5.6 (7.06) | 62.2 (6.53) | 63.8 (5.50) | 70.0 (5.33) |
| APTT | |||||
| RTB maximum | 1.08 (0.0877) | 1.04 (0.0372) | 2.08 (0.199) | 2.36 (0.224) | 2.26 (0.125) |
| RTB average | 0.988 (0.0619) | 0.976 (0.0599) | 1.67 (0.132) | 1.78 (0.115) | 1.76 (0.0866) |
FXIa:C and APTT, values are presented as mean (standard deviation).
Percentage inhibition values are calculated using the percentage from baseline values (100% - FXI, activity%/baseline FXI, activity). FXIa:C, factor XIa, coagulation activity; APTT, activated partial thromboplastin time; RTB, ratio-to-baseline.