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. 2022 Oct 19;13:1024955. doi: 10.3389/fphar.2022.1024955

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Copyright © 2022 Cui, Jiang and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of action of celastrol in neurological diseases. Similar to triptolide, celastrol has therapeutic potential in neurological diseases, with related mechanisms of action including inhibition of neuroinflammation and promotion of neuroprotection. The NF-kB signaling pathway is also involved in the action of celastrol, and celastrol can also act directly on neurons, thereby exerting neuroprotective effects. Notably, although many studies have identified neurotrophic effects of triptolide, similar results have not been reported in studies related to celastrol.