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. 2022 Oct 29;85:104319. doi: 10.1016/j.ebiom.2022.104319

Fig. 7.

Fig. 7

The activation of MER65-int in fibroblasts. a tSNE projection of fibroblasts, color-coded by cell type. b Violin plot displaying expression of canonical marker genes for fibroblast subtypes. c Relative proportion of fibroblast subtypes in different tissue types (left). Dot plot showing the distribution of fibroblast subtypes in different tissue types estimated by Ro/e (right). d Comparison of overall expression of HERVs between GBC and normal tissue cells for each fibroblast subtype. Statistical significance was evaluated by two-sided Wilcoxon rank sum test. e HERV families upregulated in GBC-derived fibroblast subtypes (adjusted p-value < 0.05 and log2FC > 0.5). f Scatter plot showing expression correlation between the indicated gene and HERV locus (top). Spearman correlation coefficient and two-tailed p-value were shown. Violin plot displaying expression of the indicated gene in iCAFs (bottom). g Heatmaps depicting expression correlation between gene and HERV family in tumor-derived myoCAFs (left, Spearman correlation coefficient was also shown) and relative expression of these correlating genes in all myoCAFs (right). h HERV families upregulated in GBC-derived endothelial cells (adjusted p-value < 0.05 and log2FC > 0.5).