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Transmission electron micrographs of mitochondria showing structural changes in hepatocytes. (a) Normal mitochondria showing an intact outer and inner membrane. The inner membrane is differentiated into the cristae, which extend deep into the electron-dense matrix. (b, c) Altered mitochondria show loss of cristae, an electron-translucent and swollen matrix, and rupture of the outer membrane (arrowheads in c). All images have the same magnification.
