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. 2022 Nov 1;12:18362. doi: 10.1038/s41598-022-23162-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of ALOX5, ALOX5AP and LTA4H in both human atherosclerotic plaque cells and murine bone-marrow derived mast cells. (A) Single-cell RNA sequencing of human atherosclerotic plaque cells revealed 14 distinct cell clusters, including one mast cell cluster (cluster 13)²⁸. In these clusters, we measured the expression of (B) ALOX5, ALOX5AP and LTA4H. (C) Expression of Kit, Alox5, Alox5ap and Lta4h in murine bone-marrow derived mast cells. Human data n = 18; murine data: n = 4. Data represent mean ± SEM.