Table 2.

Evidence profile with GRADE pro for the three meta-analyses.

Certainty assessment							No. of subjects		Size of the effect	Quality of evidence
N of studies	Study design	Risk of bias	Inconsistency	Indirect evidence	Imprecision	Other considerations	MetS+	MetS−	Difference of averages (95% CI)
Meta-analysis 1
n = 56	Observational studies		Very serious	It is not serious	It is not serious	Dose–response gradient	91,845	259,931	0,57 (0.54–0.61)	⨁◯◯◯ Very low
Meta-analysis 2
n = 17	Observational studies		Very serious	It is not serious	It is not serious	Dose–response gradient	19,165	86,883	0.53 (0.45–0.62)	⨁◯◯◯ Very low
Meta-analysis 3
n = 15	Observational studies		Very serious	It is not serious	It is not serious	Dose–response gradient	14,823	43,471	0.57 (0.48–0.66)	⨁◯◯◯ Very low

MetS metabolic syndrome, CI confidence interval.