Table 1.
Baseline demographics and disease characteristics and CSF sample methodology at first LP visit.
| All subjects | Healthy control | Premanifest | Manifest | Group membership P-value |
HC vs PM P-value |
PM vs M P-value |
|
|---|---|---|---|---|---|---|---|
| N | 497 | 139 | 179 | 179 | |||
| Age (years) | 43.94 (13.62) | 41.92 (14.20) | 36.693 (10.81) | 52.76 (10.46) | < 0.001 | < 0.001 | < 0.001 |
| Female | 253 (50.91%) | 79 (56.83%) | 98 (54.75%) | 76 (42.46%) | 0.018 | 0.710 | 0.020 |
| Caucasian | 486 (97.79%) | 136 (97.84%) | 174 (97.21%) | 176 (98.32%) | 0.775 | 0.721 | 0.479 |
| BMI | 26.16 (5.02) | 27.31 (5.56) | 25.68 (4.97) | 25.73 (4.47) | 0.006 | 0.004 | 0.919 |
| CAG | 43.03 (2.53) | N/A | 42.68 (2.26) | 43.39 (2.73) | N/A | N/A | 0.009 |
| DBS | 324.48 (113.98) | N/A | 252.66 (79.81) | 396.30 (96.49) | N/A | N/A | < 0.001 |
| cUHDRS | 15.54 (3.97) | 18.05 (1.60) | 17.65 (1.65) | 11.33 (3.56) | < 0.001 | 0.154 | < 0.001 |
| UHDRS-TFC score | 11.83 (2.41) | 12.97 (0.21) | 12.86 (0.62) | 9.91 (3.16) | < 0.001 | 0.613 | < 0.001 |
| UHDRS-TMS | 12.75 (19.54) | 0.83 (1.82) | 1.99 (3.27) | 32.89 (20.45) | < 0.001 | 0.407 | < 0.001 |
| UHDRS-IS | 93.68 (12.78) | 99.96 (0.42) | 99.55 (2.14) | 82.93 (16.40) | < 0.001 | 0.715 | < 0.001 |
| SDMT | 46.54 (17.29) | 56.12 (11.69) | 55.31 (11.20) | 29.77 (13.23) | < 0.001 | 0.555 | < 0.001 |
| SWRT | 86.83 (26.86) | 103.27 (17.19) | 98.42 (18.35) | 62.19 (22.20) | < 0.001 | 0.285 | < 0.001 |
| Number of LP attempts | 1.01 (1.60) | 1.14 (0.39) | 1.21 (0.49) | 1.28 (0.56) | 0.051 | 0.218 | 0.197 |
| Lateral decubitus | 428 (86.12%) | 117 (84.17%) | 159 (88.83%) | 152 (84.92%) | 0.419 | 0.226 | 0.275 |
|
LP site L3-L4 L4-L5 other |
250 (50.40%) 213 (42.94%) 33 (6.65%) |
80 (57.55%) 52 (37.41%) 7 (5.04%) |
86 (48.31%) 80 (44.94%) 12 (6.74%) |
84 (46.93%) 81 (45.25%) 14 (7.82%) |
0.196–0.871 | 0.129–0.831 | 0.870–0.738 |
| CSF volume | 18.96 (3.55) | 19.57 (3.77) | 19.21 (2.44) | 18.23 (4.15) | 0.002 | 0.363 | 0.009 |
| CSF RBCs count | 25.15 (171.92) | 9.66 (30.72) | 16.21 (94.32) | 46.83 (271.04) | 0.114 | 0.737 | 0.096 |
Continuous variables are reported as mean (standard deviations). Categorical variables are reported as absolute and relative frequencies.
BMI body mass index, CAG HTT CAG size, DBS Disease Burden Score, cUHDRS composite Unified Huntington’s Disease Rating Scale, TMS UHDRS Total Motor Score, TFC UHDRS Total Functional Capacity, IS UHDRS Independence Scale, SWR Stroop Word Reading test, SDMT Symbol Digits Modality Test, RBCs Red Blood Cells.