Table 4.
Univariable analysis of all adverse events, headache and back pain.
| Univariable analysis | All adverse events | Headache | Back pain | |||
|---|---|---|---|---|---|---|
| Odd ratio | P-value | Odd ratio | P-value | Odd ratio | P-value | |
| Age | 0.958 | < 0.001 | 0.971 | < 0.001 | 0.953 | < 0.001 |
| BMI | 0.989 | 0.541 | 0.987 | 0.540 | 0.990 | 0.694 |
| Sex | 1.658 | 0.004 | 1.614 | 0.022 | 1.360 | 0.225 |
| CAG | 1.054 | 0.207 | 1.027 | 0.603 | 0.991 | 0.876 |
| DBS | 0.997 | 0.003 | 0.997 | 0.044 | 0.995 | 0.001 |
| cUHDRS | 1.108 | < 0.001 | 1.138 | < 0.001 | 1.069 | 0.051 |
| Pre-M vs Control 95% CI | 1.448 [0.95–2.22] | 0.088 | 1.184 [0.73–1.91] | 0.491 | 2.079 [1.08–3.99] | 0.028 |
| M vs Control 95% CI | 0.662 [0.41–1.07] | 0.094 | 0.501 [0.28–0.89] | 0.019 | 0.914 [0.45–1.87] | 0.806 |
| HDGEC vs Control 95% CI | 1.059 [0.71–1.58] | 0.779 | 0.862 [0.55–1.36] | 0.523 | 1.435 [0.78–2.65] | 0.249 |
| TFC score | 1.182 | 0.001 | 1.214 | 0.003 | 1.138 | 0.056 |
| TMS | 0.973 | < 0.001 | 0.968 | < 0.001 | 0.972 | 0.004 |
| UHDRS-IS | 1.031 | 0.001 | 1.041 | 0.001 | 1.033 | 0.019 |
| SDMT | 1.025 | < 0.001 | 1.027 | < 0.001 | 1.014 | 0.061 |
| SWRT | 1.011 | 0.002 | 1.014 | 0.001 | 1.005 | 0.308 |
| Number of LP attempts | 1.158 | 0.395 | 1.092 | 0.669 | 1.084 | 0.746 |
| LD position | 1.047 | 0.855 | 1.111 | 0.729 | 1.110 | 0.782 |
|
Site L3-L4 vs L4-L5 Others vs L4-L5 |
1.029 2.145 |
0.881 0.017 |
0.945 1.972 |
0.800 0.062 |
1.191 1.905 |
0.526 0.142 |
| CSF volume | 0.985 | 0.522 | 1.026 | 0.412 | 1.025 | 0.522 |
| CSF RBCs count | 0.999 | 0.368 | 0.999 | 0.504 | 0.995 | 0.356 |
BMI body mass index, CAG HTT CAG size, DBS Disease Burden Score, cUHDRS composite Unified Huntington’s Disease Rating Scale, Pre-M Premanifest HD, M Manifest, HDGEC Huntington's disease gene expansion carrier, TMS UHDRS Total Motor Score, TFC UHDRS Total Functional Capacity, IS Independence Scale, SWR Stroop Word Reading test, SDMT Symbol Digits Modality Test, LD Lateral Decubitus, RBCs Red Blood Cells.