Table 5.
Baseline demographics and CSF sample methodology in relation to the development of headache post LP.
| Headache | Total | Procedures without adverse events (100%) | Procedures with Adverse events (100%) | p-value |
|---|---|---|---|---|
| N = 497 | N = 404 | N = 93 | ||
| Age | 44 (14) | 45 (14) | 41 (13) | 0.007 |
| Female | 253 (51%) | 198 (49%) | 55 (59%) | 0.078 |
| Caucasian | 486 (98%) | 396 (98%) | 90 (97%) | 0.46 |
| BMI | 26.16 (5.02) | 26.21 (5.04) | 25.91 (4.95) | 0.61 |
| HD category | ||||
| Control | 139 (28%) | 111 (27%) | 28 (30%) | 0.003 |
| Premanifest | 179 (36%) | 134 (33%) | 45 (48%) | |
| Manifest | 182 (36%) | 159 (39%) | 20 (22%) | |
| DBS | 324.48 (113.98) | 334.32 (113.63) | 280.17 (105.46) | < 0.001 |
| UHDRS-TFC score | 11.83 (2.41) | 11.68 (2.58) | 12.46 (1.28) | 0.005 |
| UHDRS- IS | 93.68 (12.78) | 92.83 (13.70) | 97.15 (6.61) | 0.004 |
| UHDRS- TMS | 12.75 (19.54) | 14.25 (20.72) | 6.29 (11.24) | < 0.001 |
| SWRT | 86.83 (26.86) | 85.07 (27.32) | 94.41 (23.17) | 0.002 |
| SDMT | 46.54 (17.29) | 45.29 (17.41) | 51.89 (15.74) | < 0.001 |
| cUHDRS | 15.54 (3.97) | 15.25 (4.11) | 16.79 (3.03) | < 0.001 |
| Number of LP attempts | 1 (0) | 1 (0) | 1 (1) | 0.85 |
| LP Site | ||||
| L4/5 | 213 (43%) | 173 (43%) | 40 (43%) | 0.93 |
| L3/4 | 250 (50%) | 204 (50%) | 46 (49%) | |
| Other | 33 (7%) | 26 (6%) | 7 (8%) | |
| Lateral decubitus | 428 (86%) | 347 (86%) | 81 (87%) | 0.76 |
| CSF volume | 19 (4) | 19 (4) | 19 (2) | 0.12 |
| CSF RBCs count | 25 (172) | 30 (190) | 6 (17) | 0.24 |
Continuous variables are reported as mean (standard deviations). Categorical variables are reported as absolute and relative frequencies.
BMI body mass index, CAG HTT CAG size, DBS Disease Burden Score, cUHDRS composite Unified Huntington’s Disease Rating Scale, TMS UHDRS Total Motor Score, TFC UHDRS Total Functional Capacity, IS UHDRS Independence Scale, SWR Stroop Word Reading test, SDMT Symbol Digits Modality Test, RBCs Red Blood Cells.