Table 1.

Nanoformulations’ list of curcumin that can be potentially applied for the treatment of CF

Nanoformulations	Experimental model/clinical study	Results	References
PEG-curcumin	Human bronchial epithelial cells in vitro	↑Aqueous solubility ↑Bioavailability	(Pandey et al. 2011)
DPI-curcumin	RAW 264.7 cells/ in vitro	High loading and sustained release of drug	(El-Sherbiny and Smyth 2012)
PLGA-curcumin	Mice/in vivo	Effective in curing ΔF508 mutation	(Cartiera et al. 2010)
Nano-curcumin (Exir Nano Sina Drug Company, Iran)	Humans/clinical study	No cytotoxicity ↓ liver metabolism ↑Gastrointestinal absorption	(Talebi et al. 2021)

DPI dry powdered inhalers, PEG polyethylene glycol, PLGA poly (lactic-co-glycolic acid)