Risk of hematoma stratified by anticoagulant (AC) and antiplatelet (AP) use. Bar chart depicting hematoma rates within 30 days of the patients’ index procedures stratified by antithrombotic use. Hazard ratios (HR), 95% confidence interval (CI), and P values are calculated using Cox proportional regression modeling. Hematoma rates varied substantially based on AC use, type (warfarin or direct oral anticoagulant [DOAC]), and with or without use of AP, which was associated with an almost doubling of hematoma risk vs no AP use (HR: 1.85, P = .0006) in the general cohort. Among the type of AC used, the risk of hematoma was higher in the warfarin group vs DOAC (HR: 1.71; 95% CI 1.00–2.90; P = .0487).