TABLE 4.

Framework of approaches in Patients customization.

Features	Trial of therapy	n-of-1 clinical trials	Aggregated n-of-1 trials	Aggregated n-of-1 case studies
Aim	For individual optimize care	Generalized knowledge individual optimize care	For individual optimize care	Generalized knowledge individual optimize care
Design	Clinical supervision or care	Experimental trial design	Clinical care	Experimental trial design
Study protocol	No	Yes	Yes	Yes
Factor determining the treatment population	Clinical need	Requirements research	Clinical need	Requirements research
Interventions	Individualized (dose, duration, route)	Standardized dose (dose, duration, route)	Individualized (dose, duration, route)	Standardized (dose, duration, route)
Analysis of data	Individual level	Individual level	Aggregated individual level	Aggregated individual level