Table 3.

Associations of HS-SIC with incident heart failure, overall and by sex

	Total sample				Women			Men
	HR*	95% CI	P value	Sex interaction P	HR*	95% CI	P value	HR*	95% CI	P value
Model 0	1.42	1.20 to 1.68	<0.0001	0.042	1.67	1.29 to 2.16	<0.0001	1.16	0.92 to 1.47	0.22
Model 1	1.20	1.01 to 1.44	0.04	0.047	1.46	1.13 to 1.90	<0.01	1.04	0.82 to 1.32	0.72
Model 2	1.18	0.98 to 1.41	0.07	0.07	1.37	1.05 to 1.79	0.02	1.03	0.81 to 1.32	0.78
Model 3	1.04	0.85 to 1.26	0.72	0.16	1.30	0.98 to 1.73	0.07	0.88	0.68 to 1.13	0.32

Model 0: HS-SIC alone.

Model 1: HS-SIC+age + sex.

Model 2: Model 1+antihypertensive medication use.

Model 3: Model 2+body mass index, systolic blood pressure, diabetes, smoking and total/high-density lipoprotein cholesterol ratio.

*Estimates are per 1-SD for HS-SIC.

HS-SIC, high spectrum signal intensity coefficient.