Table 4.

Associations of high spectrum signal intensity coefficient and relative wall thickness with incident heart failure, overall and by sex

	High spectrum SIC			Relative wall thickness*
	HR	95% CI	P value	HR	95% CI	P value
Total sample
Model 0	1.44	1.19 to 1.74	<0.001	1.42	1.21 to 1.67	<0.0001
Model 1	1.25	1.03 to 1.52	0.02	1.21	1.02 to 1.45	0.03
Model 2	1.23	1.01 to 1.50	0.04	1.17	0.97 to 1.40	0.10
Model 3	1.10	0.89 to 1.35	0.38	1.13	0.95 to 1.36	0.17
Women
Model 0	1.76	1.31 to 2.37	<0.001	1.06	0.73 to 1.53	0.76
Model 1	1.61	1.20 to 2.17	<0.01	0.83	0.56 to 1.23	0.35
Model 2	1.54	1.13 to 2.10	<0.01	0.78	0.53 to 1.17	0.23
Model 3	1.47	1.06 to 2.03	0.02	0.77	0.51 to 1.16	0.21
Men
Model 0	1.19	0.92 to 1.53	0.18	1.53	1.27 to 1.85	<0.0001
Model 1	1.10	0.86 to 1.42	0.45	1.35	1.12 to 1.64	<0.01
Model 2	1.09	0.83 to 1.41	0.51	1.32	1.09 to 1.61	<0.01
Model 3	0.95	0.72 to 1.25	0.71	1.29	1.06 to 1.58	0.01

Model 0: High spectrum signal intensity coefficient and relative wall thickness.

Model 1: High spectrum signal intensity coefficient, relative wall thickness, age and sex.

Model 2: Model 1+antihypertensive medication use.

Model 3: Model 2+body mass index, systolic blood pressure, diabetes, smoking, and total/high-density lipoprotein cholesterol ratio.

*Estimates are per 1-SD for high spectrum SIC and per 1-SD for relative wall thickness (SD=0.0634).

SIC, signal intensity coefficient.