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. 2022 Sep 24;298(11):102532. doi: 10.1016/j.jbc.2022.102532

Figure 6.

Figure 6

CX3CL1-ICD peptide confers protection against amyloid beta–induced stress.A, Neuro-2A (N2A) cells were treated with 5 μM CX3CL1-ICD peptides for 36 h. A subset of the cells was treated with amyloid beta at 24 h post-treatment with Tet-CX3CL1-ICD peptides for 12 h prior to evaluation of stress-induced markers. C, Tet34 significantly attenuated mitochondrial apoptotic markers and (E) ameliorated endoplasmic reticulum (ER) stress–induced markers. B, D, and F, bar graphs show protein expression levels normalized to the loading control. n = 3 independent experiments (n = 3 experiments; ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001, one-way ANOVA; error bars indicate ±SEM). CX3CL1-ICD, intracellular domain of CX3CL1.