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. 2022 Oct 19;13:1015221. doi: 10.3389/fneur.2022.1015221

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Copyright © 2022 Wang, Wei, Long, Wang, Yang, Wu, Li, Li, Arshad, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CENPA expression is upregulated in patients with glioma and suggests a poor prognosis. (A) Expression of CENPA in glioma and normal tissues in the GEPIA database (one-way ANOVA, *P < 0.05). (B) Survival analysis of patients with glioma in the high CENPA and low CENPA groups. Red indicates high expression and blue indicates low expression. ***P < 0.001. The expression of CENPA increased sequentially in normal samples, low-grade gliomas, and high-grade gliomas in the data retrieved from TCGA (C), GSE4290 (D), GSE16011 (E), and samples obtained from our institute (F) (Wilcoxon test, *P < 0.05, **P < 0.01, ***P < 0.001). (G,H) Immunohistochemistry of CENPA protein levels in low-grade glioma tissues (G) and glioblastoma tissues (H). (I) Immunohistochemistry revealed higher expression patterns of CENPA in glioblastoma tissues than in low-grade glioma tissues (Student's t-test, *P < 0.05, **P < 0.01, ***P < 0.001).