TABLE 6.
The performances of the related factors in predicting the occurrence of NTOVCF
| Variables | AUC (95% CI) | P value | Cut‐off value | Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | PPV (%, 95% CI) | NPV (%, 95% CI) | DE (%, 95% CI) |
|---|---|---|---|---|---|---|---|---|
| P1NP (ng/ml) | 0.576 (0.527–0.623) | 0.0064 | 23.94 | 22.6 (17.1–28.9) | 93.2 (89.0–96.1) | 75.8 (64.4–84.4) | 56.0 (54.0–58.0) | 58.9 (54.1–63.6) |
| β‐CTX (ng/ml) | 0.660 (0.613–0.705) | <0.0001 | 0.899 | 45.2 (38.3–52.2) | 87.7 (82.6–91.8) | 77.7 (70.3–83.6) | 62.9 (59.7–65.9) | 67.1 (62.4–71.5) |
| β‐CTX/P1NP (%) | 0.713 (0.667–0.755) | <0.0001 | 1.7092 | 53.9 (46.8–60.8) | 88.2 (83.2–92.1) | 81.2 (74.6–86.3) | 66.9 (63.4–70.2) | 71.5 (67.0–75.7) |
| 25(OH)D (ng/ml) | 0.591 (0.543–0.638) | 0.0009 | 20 | 44.7 (37.8–51.7) | 69.1 (62.5–75.1) | 57.8 (51.6–63.7) | 56.9 (53.2–60.6) | 57.2 (52.4–62.0) |
| PTH (pg/ml) | 0.667 (0.620–0.711) | <0.0001 | 24.6 | 51.0 (44.0–57.9) | 76.8 (70.7–82.2) | 67.5 (61.2–73.2) | 62.4 (58.6–66.0) | 64.3 (59.5–68.8) |
| ALB (g/L) | 0.743 (0.699–0.784) | <0.0001 | 35.6 | 64.4 (57.5–70.9) | 75.5 (69.2–81.0) | 71.3 (65.8–76.2) | 69.2 (64.8–73.2) | 70.1 (65.5–74.4) |
| ALB degree (n)† | 0.715 (0.669–0.757) | <0.0001 | 0 | 60.1 (53.1–66.8) | 80.0 (74.1–85.1) | 74.0 (68.1–79.1) | 68.0 (63.9–71.7) | 70.3 (65.8–74.6) |
| TC (mmol/L) | 0.591 (0.542–0.638) | <0.001 | 5.7 | 34.6 (28.2–41.5) | 84.1 (78.6–88.7) | 67.3 (59.0–74.6) | 57.6 (54.8–60.4) | 60.0 (55.2–64.7) |
| HDL‐C (mmol/L) | 0.664 (0.617–0.709) | <0.0001 | 1.44 | 43.3 (36.4–50.3) | 86.8 (81.6–91.0) | 75.6 (68.1–81.8) | 61.8 (58.7–64.8) | 65.7 (60.9–70.1) |
| HB (g/L) | 0.663 (0.616–0.708) | <0.0001 | 123 | 55.8 (48.7–62.6) | 69.1 (62.5–75.1) | 63.0 (57.5–68.3) | 62.3 (58.1–66.3) | 62.6 (57.8–67.2) |
| HB degree (n)† | 0.586 (0.537–0.633) | <0.0001 | 0 | 26.9 (21.0–33.5) | 89.6 (84.7–93.3) | 70.9 (60.9–79.2) | 56.4 (54.1–58.7) | 59.1 (54.3–63.8) |
| NACP (U/L) | 0.734 (0.689–0.775) | <0.0001 | 4.6 | 55.8 (48.7–62.6) | 80.5 (74.6–85.5) | 73.0 (66.8–78.4) | 65.8 (62.0–69.4) | 68.5 (63.8–72.8) |
| BMD (T‐score) | 0.737 (0.692–0.778) | <0.0001 | −3.5 | 56.3 (49.2–63.1) | 79.6 (73.6–84.7) | 72.2 (66.1–77.6) | 65.8 (61.9–69.5) | 68.2 (63.6–72.6) |
| BMD degree (n)† | 0.683 (0.636–0.727) | <0.0001 | 1 | 56.3 (49.2–63.1) | 79.6 (73.6–84.7) | 72.2 (66.1–77.6) | 65.8 (61.9–69.5) | 68.2 (63.6–72.6) |
| Daily avctivity (n)† | 0.600 (0.552–0.647) | <0.0001 | 0 | 83.2 (77.4–88.0) | 36.8 (30.4–43.6) | 55.5 (52.5–58.3) | 69.8 (62.0–76.6) | 59.3 (54.5–64.0) |
| FDR (%) | 0.845 (0.807–0.878) | <0.0001 | 28.49 | 78.4 (72.1–83.8) | 80.9 (75.1–85.9) | 79.5 (74.6–83.7) | 79.8 (75.2–83.8) | 79.7 (75.5–83.4) |
| FDR degree (n)† | 0.553 (0.505–0.601) | <0.0001 | 2 | 12.5 (8.3–17.8) | 98.2 (95.4–99.5) | 86.7 (69.8–94.8) | 54.3 (52.9–55.6) | 56.5 (51.7–61.3) |
| CSA (cm2) | 0.854 (0.817–0.886) | <0.0001 | 32.33 | 73.1 (66.5–79.0) | 84.6 (79.1–89.1) | 81.7 (76.5–86.0) | 76.9 (72.5–80.7) | 79.0 (74.8–82.7) |
Abbreviations: β‐CTX, b‐C‐terminal telopeptide of type I collagen; ALB, serum albumin; AUC, area under the ROC curve; BMD, bone mineral density; CI, confidence interval; CSA, cross‐sectional area; DE, diagnostic efficiency; FDR, fatty degeneration ratio; HB, hemoglobin; HDL‐C, high‐density lipoprotein cholesterol; NACP, non‐prostatic acid phosphatase; NPV, negative predictive value; P1NP, propeptide of type I procollagen; PPV, positive predictive value; R 2, correlation coefficient; TC, total cholesterol.
Note: Data were presented as value (95% CI) or % (95% CI). p value <0.05 was considered a statistical difference.