Table 2.
Univariate and Multivariate Linear Regression Analyses Assessing Baseline Characteristics of Eyes in the Diabetic Retinopathy Clinical Trial Protocol V for Associations of Fluctuations in Central Subfield Thickness
| Variable | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| Estimate | 95% CI | P Value | Estimate | 95% CI | P Value | |
| Age (10 years) | −1.60 | −3.81 to 0.61 | 0.1556 | −1.45 | −3.31 to 0.46 | 0.1271 |
| Gender (female) | 0.02 | −2.25 to 2.29 | 0.9852 | 2.18 | 0.30 to 4.06 | 0.0227 |
| Ethnicity (Hispanic) | −7.05 | −16.37 to 2.27 | 0.1374 | |||
| Race | ||||||
| American Indian | 16.79 | −17.47 to 51.04 | 0.3359 | |||
| Asian | −11.21 | −28.23 to 5.81 | 0.1959 | |||
| African American | −6.10 | −15.62 to 3.41 | 0.2078 | |||
| Native Hawaiian | 13.68 | −14.70 to 42.05 | 0.3440 | |||
| White | −5.92 | −14.71 to 2.64 | 0.1746 | |||
| Diabetes type (type 2) | −9.43 | −17.09 to −1.77 | 0.0156 | −7.37 | −13.64 to −1.11 | 0.0209 |
| Insulin use (yes) | −0.22 | −2.52 to 2.07 | 0.8475 | |||
| Baseline vision (10 ETDRS letters) | −9.47 | −14.88 to −4.07 | < 0.0006 | −1.91 | −6.54 to 2.71 | 0.4159 |
| Baseline CST (10 microns) | 2.56 | 2.25 to 2.86 | < 0.0001 | 2.51 | 2.21 to 2.82 | < 0.0001 |
| Baseline DRSS (10 levels) | 0.21 | −1.26 to 1.68 | 0.7789 | 0.32 | −0.88 to 1.52 | 0.6034 |
| Baseline systolic blood pressure (mmHg) | 0.12 | 0.004 to 0.24 | 0.0424 | 0.11 | 0.01 to 0.21 | 0.0261 |
| Baseline diastolic blood pressure (mmHg) | 0.22 | 0.025 to 0.42 | 0.0272 | 0.06 | −0.10 to 0.23 | 0.4500 |
| Treatment arm | ||||||
| Observation | 5.35 | 2.29 to 8.41 | 0.0006 | 5.04 | 2.51 to 7.58 | < 0.0001 |
| Laser | 1.55 | −1.52 to 4.61 | 0.3217 | 1.47 | −1.07 to 4.01 | 0.2558 |
| Anti-VEGF | −6.90 | −9.99 to −3.81 | < 0.0001 | −6.51 | −9.07 to −3.96 | < 0.0001 |
| Lens status (Phakic) | −4.11 | −22.82 to 14.61 | 0.6665 | |||
DRSS = diabetic retinopathy severity score; CI = confidence interval; CST = central subfield thickness; mmHg = millimeters of mercury.