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. 2022 Sep 7;82(21):4044–4057. doi: 10.1158/0008-5472.CAN-21-4443

Figure 6.

Figure 6. VRK2-methylated context is maintained in patient-relevant glioblastoma models. A, Immunoblots from 9 GBM CSC models. B, Select CSC models were cultured in CSC or non-CSC medium and immunoblotted for VRK1 and VRK2 protein. C, 7-day growth curves of the 3832 model with shRNA knockdown induced by doxycycline of the indicated genes (left), data from day 6 quantified (right) ****, P < 0.001, one-way ANOVA and Dunnett's post hoc multiple comparison test. D, Data as in (C) for the DI318 model. E, Immunoblots and (F) mRNA levels for VRK1 at 3 days after doxycycline.

VRK2-methylated context is maintained in patient-relevant glioblastoma models. A, Immunoblots from 9 GBM CSC models. B, Select CSC models were cultured in CSC or non-CSC medium and immunoblotted for VRK1 and VRK2 protein. C, Seven-day growth curves of the 3832 model with shRNA knockdown induced by doxycycline of the indicated genes (left), and data from day 6 quantified (right). ****, P < 0.001, one-way ANOVA and Dunnett post hoc multiple comparison test. D, Data as in C for the DI318 model. E and F, Immunoblots (E) and mRNA levels (F) for VRK1 at 3 days after doxycycline.