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. 2022 Aug 16;82(21):3903–3916. doi: 10.1158/0008-5472.CAN-21-3819

Figure 1.

Figure 1. Identification of cancer cells and normal fallopian tube epithelial cells. A, The workflow diagram illustrates the sampling and analysis strategies. B, Uniform manifold approximation and projection (UMAP) plot of all single cells we sequenced. Colors indicate cell types (left), patients (middle), and sampling regions (right). LN, lymph node; RL, round ligament. C, Global SCNA patterns inferred from RNA data of single cells. Each row of the heatmap represents a single cell. The color bar on the left represents the patient origin of each single cell. D, The global SCNA patterns profiled by DNA methylome data of single cells at 1-M resolution (top) and schematic diagram of the evolutionary histories of genetic lineages during tumorigenesis (bottom) for OC09. Each row of the top panel represents a single cell. Each column represents a chromosome. The representative focal aberrations within chromosome arms used to define genetic lineages are marked. The global SCNA patterns of other patients were introduced in Supplementary Fig. S2.

Identification of cancer cells and normal fallopian tube epithelial cells. A, The workflow diagram illustrates the sampling and analysis strategies. B, Uniform manifold approximation and projection (UMAP) plot of all single cells we sequenced. Colors indicate cell types (left), patients (middle), and sampling regions (right). LN, lymph node; RL, round ligament. C, Global SCNA patterns inferred from RNA data of single cells. Each row of the heatmap represents a single cell. The color bar on the left represents the patient origin of each single cell. D, The global SCNA patterns profiled by DNA methylome data of single cells at 1-M resolution (top) and schematic diagram of the evolutionary histories of genetic lineages during tumorigenesis (bottom) for OC09. Each row of the top panel represents a single cell. Each column represents a chromosome. The representative focal aberrations within chromosome arms used to define genetic lineages are marked. The global SCNA patterns of other patients were introduced in Supplementary Fig. S2.