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. 2022 Aug 24;12(11):2586–2605. doi: 10.1158/2159-8290.CD-22-0200

Figure 5.

Figure 5. Proteogenomic features associated with LIG1. Heat map showing copy number, mRNA, and protein levels of LIG1, which are significantly (Wilcoxon rank sum test) lower (blue) in non-pCR tumors. Corresponding box plots show that tumors with low-level copy loss of LIG1 (GISTIC = −1, likely single copy-number loss) display significantly higher chromosomal instability and MGPS and significantly lower signature 3 (COSMIC mutational signature associated with HRD) than tumors that are wild-type (WT) or show gain of CNA (GISTIC ≥0). Wilcoxon rank sum tests and t tests were used to compare LIG1-loss cases with LIG1-intact (WT/gain) cases. HR, homologous recombination; MSI, microsatellite instability; NA, not available.

Proteogenomic features associated with LIG1. Heat map showing copy number, mRNA, and protein levels of LIG1, which are significantly (Wilcoxon rank sum test) lower (blue) in non-pCR tumors. Corresponding box plots show that tumors with low-level copy loss of LIG1 (GISTIC = −1, likely single copy-number loss) display significantly higher chromosomal instability and MGPS and significantly lower signature 3 (COSMIC mutational signature associated with HRD) than tumors that are wild-type (WT) or show gain of CNA (GISTIC ≥0). Wilcoxon rank sum tests and t tests were used to compare LIG1-loss cases with LIG1-intact (WT/gain) cases. HR, homologous recombination; MSI, microsatellite instability; NA, not available.