Table 1.

The formulas of the three most commonly used GRS.

Category	Calculation	Description
SGRS	$\text{GRS}={\displaystyle \sum _{\text{i}=1}^{\text{I}}{\text{G}}_{\text{i}}}$	Calculated as the sum of the risk alleles (0, 1, 2) of each of the variants.
wGRS	${\text{β}}_{\text{i}}=\ln ({\text{OR}}_{\text{i}})$ $\text{GRS}={\displaystyle {\sum }_{\text{i}=1}^{\text{I}}{\text{β}}_{{\text{OR}}_{\text{i}}}{\text{G}}_{\text{i}}}$	Calculated based on the number of risk alleles weighed by their effect sizes reported in previous GWAS
DL-GRS	$\text{GRS}={\displaystyle {\sum }_{\text{i}=1}^{\text{I}}{\text{β}}_{\text{i}}{\text{G}}_{\text{i}}}$	The weights were derived from the existing original data, and the logistic regression model was fitted with these data. The SNP effect estimated in the model was used as the weight to calculate the OR weights and formulas of all SNPs included in the model